Search results for " Dairying"

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Genome-wide association study between CNVs and milk production traits in Valle del Belice sheep.

2019

Copy number variation (CNV) is a major source of genomic structural variation. The aim of this study was to detect genomic CNV regions (CNVR) in Valle del Belice dairy sheep population and to identify those affecting milk production traits. The GO analysis identified possible candidate genes and pathways related to the selected traits. We identified CNVs in 416 individuals genotyped using the Illumina OvineSNP50 BeadChip array. The CNV association using a correlation-trend test model was examined with the Golden Helix SVS 8.7.0 tool. Significant CNVs were detected when their adjusted p-value was <0.01 after false discovery rate (FDR) correction. We identified 7,208 CNVs, which gave 365 C…

0301 basic medicineFalse discovery rateCandidate geneDNA Copy Number VariationsGenotypeSciencePopulationGenomic Structural VariationQuantitative Trait LociGenome-wide association studyQuantitative trait locusBiology03 medical and health sciencesSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoAnimalsLactationCopy-number variationeducationGeneGeneticseducation.field_of_studyMultidisciplinarySheepBiochemistry Genetics and Molecular Biology (all)QAnimals chromosome mapping dairying female genome-Wide association study genotype lactation sheep DNA copy number variations quantitative trait loci0402 animal and dairy scienceRChromosome Mapping04 agricultural and veterinary sciences040201 dairy & animal scienceDairying030104 developmental biologyAgricultural and Biological Sciences (all)MedicineFemaleGenome-Wide Association StudyResearch ArticlePLoS ONE
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Absence of the lactase-persistence-associated allele in early Neolithic Europeans.

2007

Lactase persistence (LP), the dominant Mendelian trait conferring the ability to digest the milk sugar lactose in adults, has risen to high frequency in central and northern Europeans in the last 20,000 years. This trait is likely to have conferred a selective advantage in individuals who consume appreciable amounts of unfermented milk. Some have argued for the “culture-historical hypothesis,” whereby LP alleles were rare until the advent of dairying early in the Neolithic but then rose rapidly in frequency under natural selection. Others favor the “reverse cause hypothesis,” whereby dairying was adopted in populations with preadaptive high LP allele frequencies. Analysis based on the cons…

medicine.medical_treatmentPopulationLactoseBiologyDNA MitochondrialPolymorphism Single NucleotideBone and BonesWhite PeopleNOLactose IntolerancemedicineHumansAlleleeducationSelectionAllele frequencyAllelesHistory AncientLactaseGeneticseducation.field_of_studyMultidisciplinaryNatural selectionAncient DNAHaplotypeLactaseEmigration and ImmigrationBiological SciencesAncient DNA Dairying SelectionEuropeDairyingLactase persistenceAncient DNAGenetics PopulationTandem Repeat SequencesToothProceedings of the National Academy of Sciences of the United States of America
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